GRAPEFRUIT – The Killer Fruit!

Occasionally, I hear news reports regarding the dangers of eating grapefruit whileMB900436914 on certain medications. This is not new information and I have to remind myself that many are still unaware of this very serious drug-food interaction.

The medical community identified this harmful interaction at least ten years ago and now pharmacists routinely attach alert notices to certain prescription medications involved in these interactions.

The new information here is that the number of drugs that can cause such a deadly interaction with grapefruit has doubled in just the last few years.  At present, more than 85 drugs interact with grapefruit to cause injury, 43 of which cause serious or deadly interactions.

The list of drugs that interact with grapefruit now includes many blood pressure medications, most of the cholesterol-lowering drugs, certain cardiac drugs, some anti-seizure medications, specific chemotherapy drugs and a few antibiotic medications.

MB900431033Sometimes a news anchor will warn the public to stop taking their medications and call their physicians for alternatives. That advice may be premature if there is not another safer medication that can be substituted. The easier solution and a much better recommendation would be to STOP eating grapefruit!

Many of the drugs that interact with grapefruit are maintenance medications, those that patients take every day for chronic medical conditions. If a patient is achieving acceptable therapeutic effects with a drug therapy, it’s considered irresponsible to discontinue that drug in favor of a specific food choice.

As healthy and tasty as grapefruit is, if taken with certain medications it can be deadly.  As little as one-half grapefruit, or the equivalent in juice, can interfere with the metabolism of certain drugs.  A chemical in grapefruit called furanocoumarin causesMH900400871 certain drugs to stay in the body much longer than expected and this creates an overdose effect when subsequent drug doses are given.

Patients have died from respiratory failure, kidney failure and internal bleeding as a result of this accumulated drug effect. The problem remains a public health hazard for two specific reasons.

First, many people don’t read warning labels and, secondly, people don’t associate a food as simple and healthy as grapefruit as having a deadly effect.

And the problem is becoming more widespread as additional new drugs become available that have this potential for interaction with grapefruit.

It’s a much more responsible plan to eliminate grapefruit from the diet than it is to find a replacement drug, particularly if that drug is working well to control a medical condition.

Thoughts? Comments? I’d love to hear them!

About James J. Murray, Fiction Writer

With experience in both pharmaceutical manufacturing and clinical patient management, medications and their impact on one’s quality of life have been my expertise. My secret passion of murder and mayhem, however, is a whole other matter. I’ve always loved reading murder mysteries and thrillers, and longed to weave such tales of my own. Drawing on my clinical expertise as a pharmacist and my infatuation with the lethal effects of drugs, my tales of murder, mayhem and medicine will have you looking over your shoulder and suspicious of anything in your medicine cabinet.
This entry was posted in About James J. Murray, About Medications/Pharmacy, Blog Writers, Deadly Food-Drug Interactions, Deadly Grapefruit, Food-Drug Interactions, Furanocoumarin, Furanocoumarin and Grapefruit, Grapefruit and Drugs, Grapefruit as a Public Health Issue, Grapefruit-Drug Interactions, How Grapefruit Kills, Medication Safety Issues, New Drug Research, Pharmacist Errors, Prescription Trends, The Practice of Pharmacy, Using Grapefruit to Kill and tagged , , , , , , , , , , , , , , , , , , , , , , , , , , , , , . Bookmark the permalink.

8 Responses to GRAPEFRUIT – The Killer Fruit!

  1. Jim,
    The solution is obvious: make grapefruit a prescription drug.

  2. ggiammatteo says:

    great post, Jim. I was aware there were a few drugs that interacted with it but had no idea it was so many.

  3. Reblogged this on Linda Williams Stirling and commented:
    This is a good warning to heed. Both my doctor and my pharmacist long ago warned me off grapefruit because of the potential drug interactions. If you’re on any of these types of medicines, double-check the list of drugs that interact. Keep yourself safe.

    Take care,
    Linda Williams Stirlig

  4. Thanks for the reblog, Linda. It’s much appreciated! All the best to you.

  5. John Chapman says:

    Added this to my Tweet list – it’ll go out about every 17 days

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